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FDA warns of death, liver injury risks from Intercept's drug
The US Food and Drug Administration (FDA) warned on Thursday that Intercept Pharmaceuticals Inc's drug Ocaliva was being incorrectly dosed in some patients with a rare liver disease, increasing the risk of liver injury and death. The FDA warning comes two weeks after Intercept gave healthcare providers prescribing information for Ocaliva and flagged reports of liver failure and deaths. Nineteen deaths and 11 cases of serious liver injury were associated with the use of Ocaliva, the FDA said.
Trimalleolar fracture: Recovery, surgery, and outlook
Surgical repair is usually recommended for a trimalleolar fracture, which may involve screws, metal plates, and wiring. As a trimalleolar fracture is considered unstable, doctors usually recommend surgery as treatment. Surgery on the medial malleoli can reduce the risk of the fracture not healing and allow the person to start moving their ankle earlier. A trimalleolar fracture of the ankle can often be caused by high impact, such as from a sports or car accident.
Too much or too little magnesium can raise dementia risk
A new study published in the journal Neurology suggests that both very high and very low levels of magnesium may put people at risk of developing dementia. The participants did not have dementia at the beginning of the study - that is, between 1997 and 2008. Magnesium levels were divided into quintiles, or fifths; the researchers examined the association between dementia and serum magnesium using the third quintile as a reference.
U.S. safety board: Train-crash engineers had sleep disorders
The engineers in two New York City area commuter train crashes suffered from undiagnosed sleep disorders, the US National Transportation Safety Board said on Thursday. The Centers for Disease Control says being overweight puts individuals at a higher risk of sleep apnea. The safety board said the brakes were working on the New Jersey Transit train traveling at 8 miles per hour 38 seconds before the crash. The 48-year-old engineer underwent a home sleep study in October that concluded he had severe sleep apnea.
How do parents influence new genetic mutations in children?
Dr Kari Stefansson and his colleagues are looking at how the parents' age and sex determine new genetic mutations in the offspring. A new study has investigated how mothers and fathers cause new genetic mutations in their children, and how some of these mutations may lead to negative outcomes. For instance, recent studies have revealed the importance of genetic factors to conditions including Alzheimer's disease, brain cancer, and diabetes.
Many drug companies fail to conduct timely safety checks on medicines after FDA approval
In the rush to approve new medicines, the US Food and Drug Administration often requires drug companies to study possible side effects and alternative doses for medicines once they hit the broader market. The problem is, the faster you get them on the market, the more open questions there are about their safety or the best dose. One of four drug companies contacted by Reuters Health provided evidence that the information about its post-approval registry reported by the Woloshin team is inaccurate.
The Path to Digital Transformation in Life Sciences: How to get started with IoT
The concept of digital transformation is the leveraging of digital technology to change the way businesses operate. In pharma and biotech the greatest area of opportunity to realize digital transformation lies in connecting the ecosystem that supports R&D - instruments, data, and people. The ability to build group buy-in prior to full integration can streamline the ultimate path to digital transformation by preventing disruption and/or dissatisfaction.
Cancer risk higher in children with inflammatory bowel disease
Researchers have found that cancer risk is higher among children affected by inflammatory bowel disease, and that this risk lasts into adulthood. A new study of people living in Sweden has found that children with inflammatory bowel disease have a higher risk of cancer - especially gastrointestinal cancers - both in childhood and in later life, compared with individuals without the disease.
Papillary urothelial carcinoma: Treatment and outlook
In this article, we take a look at symptoms, causes, and treatment options for papillary urothelial carcinoma. People with papillary urothelial carcinoma will probably want to know from their doctor how well their cancer will respond to treatment. This treatment method is normally part of a treatment plan for people with papillary urothelial carcinoma that is stage 1 or higher. Instead, the survival rates are estimates that doctors and people with papillary urothelial carcinoma can use to make better decisions regarding treatment options.
Nestle to cut jobs at French skin health R&D center
Nestle plans to cut up to 450 jobs at a Galderma research and development center in southern France, the Swiss company said on Thursday, as it seeks to make the underperforming skin health business more efficient. Galderma, which Nestle took over from its joint venture partner L'Oreal in 2014, will cut as many as 450 of 550 jobs at its R&D center in Sophia Antipolis near Nice.
Africa to get state-of-art HIV drugs for $75 a year
As well as improving treatment, the drug combination should also reduce the need for more expensive second- and third-line drugs. Around 37 million people around the world are infected with HIV, according to the United Nations AIDS agency UNAIDS. That represents remarkable progress in the past 20 years, driven by the availability of a first wave of cheap generic drugs from Indian companies.
Nestle to cut up to 450 jobs at Galderma research center in France
Nestle said it plans to cut up to 450 jobs at a research and development center for its skin health business Galderma in southern France, as it seeks to make the underperforming unit more efficient. Nestle's Galderma business, which Nestle took over from its joint venture partner L'Oreal in 2014, will cut as many as 450 of 550 jobs at the R&D center in Sophia Antipolis near Nice, a company spokesman said on Thursday.
Michael Phelps: A Golden Shoulder to Lean On
Nicole Phelps recalled her husband saying several times, with increasing urgency, We have to convince him to come home with us. Over the summer, Phelps said, he met an 11-year-old boy in California who had appeared in a documentary about anxiety. At the end of the conversation, Phelps said, the boy told him, I have more in common with Michael Phelps than I ever thought. Together, Nicole Phelps said, they have discovered groups that offer therapy by video links and even by text or email.
Thirst: Our brains tell us when to stop drinking
Scientists are beginning to unravel the sophisticated mechanisms that stop us from drinking too much water, and the answer lies in the brain. The brain's thirst control circuit is a small region in the forebrain called the lamina terminalis (LT). A study published last week in the journal Science demonstrated that thirst creates an uncomfortable feeling in mice, which is alleviated by drinking. The authors explain that cold drinks are already known to be more thirst quenching, as are sour, flavored, and carbonated drinks.
Are e-cigarettes bad for the heart? Study sheds light
Research published this week in the Journal of the American Heart Association investigates the potential heart health implications of non-smokers using nicotine-based e-cigarettes. Many believe that the tar - not the nicotine - is what leads to increased cancer and heart attack risks. In total, 33 healthy volunteers - none of whom smoke cigarettes or e-cigarettes - were involved in the study.
Five effective essential oils for headaches
This article explores five of the best essential oils for treating headaches, as supported by scientific evidence. Many people with frequent headaches choose to seek out alternative treatments such as essential oils. There are a number of studies that show specific essential oils may be beneficial for headaches. A 2012 study suggests that the inhalation of lavender essential oil can be a safe and effective treatment to manage migraine headaches.
Poliovirus kills off cancer cells, stops tumor regrowth
The modified poliovirus appears to enable T cells to attack cancer cells . Researchers from Duke University in Durham, NC, may have discovered a new way of killing off cancer cells. Then, the poliovirus starts to attack the malignant cells, triggering the release of antigens from the tumor. Dendritic cells are cells whose role it is to process antigens and present them to T cells, which are a type of immune cell.
Merck KGaA, Pfizer's cancer drug Bavencio gets EU nod
European regulators on Thursday granted market approval for Merck KGaA and Pfizer's immuno-oncology drug Bavencio to treat a rare and aggressive type of skin cancer called Merkel cell carcinoma. In May, Bavencio was approved by the US Food and Drug Administration to treat bladder cancer and in March to treat Merkel cell carcinoma. Bavencio, also known as avelumab, belongs to a class of drugs called PD-L1 or PD-1 inhibitors that help the immune system attack cancer by blocking a mechanism tumors use to evade detection.
Florida Nursing Home Listed Dead Resident as 'Resting in Bed,' State Says
Eight of the residents died that day, either at the home, known as the Rehabilitation Center at Hollywood Hills, or at Memorial Regional Hospital. More than 100 were taken to Memorial and other hospitals, and many have now been moved to new nursing homes. Sign Up You agree to receive occasional updates and special offers for The New York Times's products and services.
Republicans plan healthcare vote, Obama and TV host denounce bill
Senate Republicans announced plans to vote next week on their latest bid to scuttle Obamacare even as a popular comedian who has become part of the US healthcare debate denounced the bill and former President Barack Obama on Wednesday warned of real human suffering. Avalere Health, a healthcare consultancy whose clients include hospitals and insurers, forecast that the bill would reduce federal funding to states by $215 billion through 2026, with 34 states facing cuts.

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